P109 Exercise capacity and physical activity in patients with CF: data from the UK CF Gene Therapy Consortium (UKCFGTC) ‘Run-In’ Study

Introduction Exercise capacity is predictive of mortality in CF. Objective measurement of daily physical activity may be related to exercise capacity and both may be useful outcome measures in interventional trials. Participants in this CF study had a field-based estimate of exercise capacity and objective measurement of physical activity at each study visit. Methods Participants wore a pedometer for 7 days prior to each visit. At each visit, London patients performed a standard incremental shuttle-walk test and Edinburgh patients a modified shuttle test (in which running was allowed). Data are expressed as mean (SD). Results Data were analysed from 192 patients over 648 visits. Age at enrolment was 24 (11.9) years (London) and 20.8 (9.9) (Edinburgh) (p=0.052); FEV 1 was 67 (17.7)% and 79 (19.5)% for each site respectively (p 1 % predicted (r=0.24, p Conclusions No changes were detected in exercise capacity or daily activity levels over time. Between site differences were observed in both measures; however, these populations also differ in age and FEV 1 . The modified shuttle test performed in Edinburgh appeared to better correlate with clinical markers than the standard incremental shuttle test performed in London, and is independent of height. We believe that testing exercise capacity is important in CF and we plan to investigate the other testing methods in the run up to our Multi Dose Gene Therapy Trial.