Phosphoryl chloride induced ring contraction of 1,4-benzodiazepinones to chloromethylquinazolines

Donald W. Combs,Jeffery B. Press,Dennis M. Mulvey,Yolanda Gray Nuñez,Stanley C. Bell

Phosphoryl chloride induced ring contraction of 1,4-benzodiazepinones to chloromethylquinazolines

1986

Donald W. Combs
Jeffery B. Press
Dennis M. Mulvey
Yolanda Gray Nuñez
Stanley C. Bell

A ring contraction of 1,4-benzodiazepin-2-one to 2-chloromethylquinazoline in phosphoryl chloride is described. The intermediacy of an aziridinoquinazoline is proposed.

Keywords:

Reaction intermediate
Phosphoryl chloride
Organic chemistry
Photochemistry
Bicyclic molecule
Lactam
Chemistry
Contraction (grammar)
Stereochemistry

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