SYNTHESIS OF p-AMINO-L-PHENYLALANINE DERIVATIVES WITH PROTECTED p-AMINO GROUP FOR PREPARATION OF p-AZIDO-L-PHENYLALANINE PEPTIDES

For the synthesis of p-azidophenylalanine peptides, the p-amino group of p-amino-L-phenylalanine is protected with the Z- or Boc residue via the copper complex or by specific acylation at pH 4.6. The α-amino or α-carboxy group is blocked by a protecting group (Boc, Ddz, OMe respectively Z, Nps, Ddz), which can be removed selectively. The synthesis of nine derivatives of p-amino-L-phenylalanine for incorporation into the peptide chain is described. The p-amino-phenylalanine is converted to p-azidophenylalanine without affecting disulfide bridges.