Blastocyst euploidy and implantation rates in a young (<35 years) and old (≥35 years) presumed fertile and infertile patient population

Objective To examine the relationship between blastocyst euploidy and implantation rates in a presumed fertile patient population. Design Retrospective analysis. Setting Private IVF clinic. Patient(s) IVF patients undergoing comprehensive chromosome screening (CCS). Intervention(s) Embryo biopsy at the blastocyst stage with preimplantation genetic screening using CCS. Main Outcome Measure(s) Euploidy, chemical pregnancy, and implantation rates. Result(s) There was no significant difference in the number of euploid blastocysts between presumed fertile (68/118, 57.6%) and infertile (75/132, 56.8%) patients Conclusion(s) When subdivided by maternal age, no significant difference was seen in blastocyst euploidy rates between presumed fertile and infertile patients; however, chemical pregnancy and implantation rates were significantly higher in a presumed fertile patient population even when transferring only euploid blastocysts. This would indicate that infertility, as a disease, may encompass other aspects such as uterine or other unknown embryological factors that can influence outcomes.