Activin Type II Receptor Ligand Signaling Inhibition After Experimental Ischemic Heart Failure Attenuates Cardiac Remodeling and Prevents Fibrosis

Estibaliz Castillero,Hirokazu Akashi,Marc Najjar,Ruiping Ji,Lea Maria Brandstetter,Catherine Wang,Xianghai Liao,Xiaokan Zhang,Alexandra Sperry,Marcia Gailes,Karina Guaman,Adam Recht,Ira Schlosberg,H. Lee Sweeney,Ziad A. Ali,Shunichi Homma,Paolo C. Colombo,Giovanni Ferrari,P. Christian Schulze,Isaac George

Activin Type II Receptor Ligand Signaling Inhibition After Experimental Ischemic Heart Failure Attenuates Cardiac Remodeling and Prevents Fibrosis

2019

Myostatin (MSTN) is a transforming growth factor (TGF)-β superfamily member that acts as a negative regulator of muscle growth and may play a role in cardiac remodeling. We hypothesized that inhibi...

Keywords:

Regulator
Biochemistry
Cell biology
Fibrosis
Cardiac fibrosis
Heart failure
Transforming growth factor
Biology
Muscle hypertrophy
Receptor
Myostatin
Cardiac function curve
Internal medicine
Unfolded protein response
Myocardial infarction
Endocrinology

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