[Use of aminoglycoside antibiotic gentamycin in extremely premature infants--administration schedule and suggested dosage based on pharmacokinetic studies in plasma].

: The pharmacokinetics of Gentamycin administered to 22 infants intravenously at currently recommended doses (2-2.5 mg every 24 h for infants less than 7 days of life and 28 g.a. and 12 h for infants 32 g.a). The results showed a statistically significant relation between half-life and postconsiptional age and direct correlation between total body clearance and postconsiptional age. These pharmacokinetics data were used to calculate a new dosage schedule for preterm infants. Ondoing therapeutic drug monitoring is essential to tailor the dosage to the individual patient. Gentamycin.