Enantioselective Total Synthesis of Otteliones A and B

Enantioselective total synthesis of otteliones A and B was accomplished. The key steps are radical cyclization of an alpha-iodoketone to construct the cis-hydrindanone skeleton and Suzuki−Miyaura coupling to incorporate the aromatic group. (+)-Ottelione A was converted to (−)-ottelione B on treatment with NaOH in THF.