Methylcobalamin-containing freeze-dried preparation and a production method thereof

The present invention can be used in high concentration therapy of methylcobalamin which has excellent stability over time, it provides a freeze-dried preparation containing a high content of methylcobalamin. According to the present invention, comprising methylcobalamin or a pharmacologically acceptable salt thereof, and an excipient, wherein the excipient discloses lyophilized formulation is at least an amorphous state. In the freeze-dried preparation, when the excipient comprises the sugar and sugar alcohol, based on the total weight of the sugars and sugar alcohols, that containing said excipient in an amorphous state of at least 20 wt% and features.