The biological and pathological features of the breast cancer mouse model MMTV-PyMT

Objective To investigate the biological features of the transgenic mouse model and the pathological changes during its life span.Methods The MMTV-PyMT mouse raised in SPF conditions,and the mice breed was recorded everyday.Mast adenoma of MMTV-PyMT mice have been observed by counting and measuring the tumors,and HE staining for pathological development.Results MMTV-PyMT mice were well bred in our lab for nine generations and totally 400 offspring were obtained.The tumor biological feature was obvious in MMTV-PyMT mice,palpable Mast adenoma occur in 9 week old and pulmonary metastasis was occur in 11 weeks old.Number and size of tumors increased when the mice grow up.Conclusions The MMTV-PyMT transgenic mouse model was well kept and bred,breart tumors can be spontaneuos stably.This can be a typical animal model for breast carcinoma research.