First detection of CMY-2 plasmid mediated β-lactamase in Salmonella Heidelberg in South America

Salmonella enterica serovar Heidelberg ranks among the most prevalent causes of human salmonellosis in the United States and Canada, although it has been infrequently reported in South American and European countries. Most Salmonella infections are self-limiting; however, some invasive infections require antimicrobial therapy. In this work we characterized an oxyimino-cephalosporin resistant S. Heidelberg isolate recovered from an inpatient in a Buenos Aires hospital. CMY-2 was responsible for the β-lactam resistance profi le. S. Heidelberg contained a 97 kb plasmid belonging to the Inc N group harboring bla CMY-2 . ISEcp1 was located upstream bla CMY-2 driving its expression and mobilization. The isolate belonged to sequence type 15 and virotyping revealed the presence of sopE gene. In this study we identifi ed the fi rst CMY-2 producing isolate of S. Heidelberg in Argentina and even in South America. © 2013 Asociacion Argentina de Microbiologia. Published by Elsevier Espana, S.L. All rights reserved.