galacto-C- Furanosides (I, β- C -Lyxose)

This chapter reviews the synthesis of C -furanosides of the galacto - configuration series. Approaches include nucleophilic and radical additions, reductions at the anomeric carbon, hydrogenation of exo -glycals, stereospecific and stereoselective cyclization reactions, stereochemical inversions at C-2 or C-3, and cycloaddition reactions. The principal stereocontrol elements are bicyclic induction, internal delivery, and thermodynamic control.