Changes in orthogonal ECG in hypertensive patients taking different antihypertensive therapy

Aim. To ascertain changes in orthogonal ECG in hypertensive patients taking different antihypertensive treatment. Material and methods. Orthogonal ECG parameters and those of 24-h blood pressure monitoring (BPM) were examined before and after antihypertensive treatment with different drugs in 95 hypertensive patients aged 47±1 years. Of them, 14 patients received trandolapril+verapamil SR for 2 months, 13 patients - candesartan for 3 months, 25 patients - ramipril for 5 months, 26 patients - carvedilol for 4 months, 10 patients - atenolol for 8 months, 7 patients - doxasozine for 5 months. Results. 24-h BPM parameters improved in all the groups . Initially, conventional ECG evidence on left ventricular hypertrophy was not seen in 86% patients. Dynamics of orthogonal ECG showed that parameters which increase in left ventricular hypertrophy decrease in response to treatment in patients with baseline values above the median. Parameters G and Gx,which in left ventricular hypertrophy diminish, rise significantly in patients with baseline values under median due to therapy. Treatment with impact on renin-angiotensin system reduced voltage parameters of orthogonal ECG, improved G characterizing repolarisation. Treatment with adrenoreceptors blockers reduced IADI. Conclusion. The analysis of parameters of orthogonal ECG reveals positive dynamics in response to treatment in patients with insignificant changes on ECG in short follow-up. Drugs of different groups change different parameters of orthogonal ECG.