Five-year observation of the relationship between body mass index and glycated hemoglobin in children with Type 1 diabetes mellitus

AbstractBackground: Poor metabolic control is a well-recognized risk factor for cardiovascular disease. However, the relationship between such factor as body weight and metabolic control in children with diabetes mellitus type 1 (DM1) is unclear. The aim of this study was to examine the relationships between body weight, age, metabolic control, sex, and form of insulin therapy in children with DM1.Methods: This was a retrospective study of children with DM1 treated at one diabetes center for a minimum of 5 years since diagnosis.Results: Median body mass index standard deviation score (BMI-SDS) increased annually (p = .0042) on average 0.08 ± 0.27 per year throughout the observation. As well HbA1c and daily dose insulin increased annually (p < .0001; p < .0001, respectively) on average by 0.43 ± 0.79 and by 0.13 ± 0.17 per year. Percentage of good metabolic control – HbA1c cut-off of 6.5% – gradually worsened in all patients over the 5 years, with a higher percentage of girls experiencing poor metabolic co...