FSH RECEPTOR AUTOANTIBODY ASSOCIATED PRIMARY OVARIAN INSUFFICIENCY SUCCESSFULLY TREATED WITH CORTICOSTEROIDS: A CASE REPORT

Abstract: Objective To report a case of successful controlled ovarian stimulation (COH) for oocyte cryopreservation in a patient with autoimmune primary ovarian insufficiency (POI) and polyglandular autoimmune syndrome (PGAS) type 2. Design Case report. Setting Private IVF clinic. Patient(s) 25-year-old G0 with autoimmune POI and PGAS type 2. Intervention(s) Diagnosis of autoimmune interference with FSH signaling, with subsequent high-dose corticosteroid immune suppression and successful oocyte cryopreservation. Main Outcomes Measure(s) Successful stimulation with exogenous gonadotropins, oocyte retrieval and cryopreservation. Result(s) Retrieval and cryopreservation of 36 metaphase-II (MII) oocytes. Conclusion(s) Scrutiny of POI cases will facilitate identification of a subset of patients in whom immune suppression with short-term, high-dose corticosteroids may enable successful COH.