In vitro activity of Jinghuaweikang capsules against clinical isolates of antibiotic-resistant Helicobacter pylori

[Objective]To evaluate the activity of Jinghuaweikang capsules(JC)against clinical isolates of antibiotic-resistant H.pylori and the synergistic activity of JC combining with metronidazole or clarithromycin against antibiotic-resistant H.pylori.[Methods]In this in vitro study,JC,JC combining with metronidazol or clarithromycin were investigated for bacteriostatic activity using agar dilution or E-test methodology,and H.pylori 26695were examined.[Results]JC and its ingredient Chenopodium ambrosioides were active against H.pylori 26695and antibiotic-resistant H.pylori(mean inhibitory concentration,16～64mig/L),and they were synergistic with antibiotics.[Conclusion]JC had inhibitory activity to H.pylori 26695and antibiotic-resistant H.pylori strains in vitro,and it was synergistic with metronidazol or clarithromycin.