Butein activates p53 in hepatocellular carcinoma cells via blocking MDM2-mediated ubiquitination

Yuanfeng Zhou,Kuifeng Wang,Ni Zhou,Tingting Huang,Jiansheng Zhu,Jicheng Li

Butein activates p53 in hepatocellular carcinoma cells via blocking MDM2-mediated ubiquitination

2018

Yuanfeng Zhou
Kuifeng Wang
Ni Zhou
Tingting Huang
Jiansheng Zhu
Jicheng Li

Introduction In this study, we aimed to investigate the effect of butein on p53 in hepatocellular carcinoma (HCC) cells and the related molecular mechanisms by which p53 was activated.

Keywords:

Butein
Immunology
Ubiquitin
Hepatocellular carcinoma
Mdm2
Medicine
Cancer research
Flow cytometry
Apoptosis
In vivo
Blot
Cell growth
Reporter gene

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