Nevirapine Immediate release tablets by liquisolid compaction technique

The aim of the study was to enhance the solubility of poorly soluble Nevirapine by liquisolid compaction technique and to formulate them to a stable dosage form.[1] Nevirapine first of its kind, a non-nucleoside reverse transcriptase inhibitor that got approved in the year 1996. Nevirapine Immediate-release tablets were prepared by using liquisolid compaction technique.[2] Various compositions of non-aqueous solvents like PEG 400, PEG 600, Solutol® HS15 and Synperonic® PE/L61are used in solubilizing nevirapine and convert the solid form of drug into liquid medicament which is then adsorbed on to carrier like Neusilin and coating materials like Aerosil 200 along with a super disintegrant sodium starch glycolate. Carrier and coating ratios are altered and formulated as liquisolid compacts. [3]Nevirapine liquisolid compacts preformulation studies and in-vitro dissolution studies were carried out using USP II (paddle type) dissolution apparatus 0.1N HCl at 37oC. Nevirapine --------drug release was found to be maximum with solutol® HS15 as the non-aqueous solvent and exhibited maximum drug release of 100% within 45min for formulation F9. In conclusion Nevirapine liquisolid compacts turned out to be a potential tool in enhancing the solubility using solutol ® HS15 as the nonvolatile solvent.