Ozone Therapy in Patients with Retinitis Pigmentosa

The aim of this study is to determine the efficacy of ozone therapy in patients with Retinitis Pigmentosa (RP). A controlled, randomized, double blind clinical trial involving 68 patients was performed. Patients were divided into 2 groups: ozone, patients treated with ozone by rectal administration (dose=10 mg), during 15 sessions; control, as ozone group, but using oxygen. The main outcome variable was the visual field area (VFA). Results demonstrated a significant improvement (SI) in 88.2% of patients treated with ozone in comparison with 23.5% achieved in the control group. In the ozone group, VFA tend to stabilize beyond a mean time of 6.83 months with a loose in SI afterward. A temporal positive effect of ozone therapy. Over the natural course of RP, was found.