Purinenucleoside analogs. 2. 9-(1-Alkoxyethyl-1)-6-substituted purines

Vinyl ethers react with 6-chloro- and 6-methylthiopurines in acid medium to give 9-(1-alkoxyethyl-1)-6-chloro- and 6-methylthiopurines. The 6-chloro compounds were used to prepare 9-(1-alkoxyethyl-1)-6-mercaptopurines. All the synthesized compounds proved to be inactive against lympholeucosis P 388, and Lewis carcinona grafted under kidney capsules in mice.