Threading Microarrays into Novel Applications

Introduction HSP90 is known as a stabilizer of the proteome and is required for many newly synthesized proteins and introducing damaged proteins back into the refolding chaperone cycle. Due to its key position and interaction with several hundreds of proteins in a cell, it is a target for noxious cells and a responsive sensitive biomarker for cellular stress. Cellular stress is when unfolded proteins are formed by, e.g. mutational events, changes in the osmolality, or redox status. One challenge is to monitor and discriminate the cellular answers to relevant and reliable signals. The aim of this narrative review is to provide an overview of currently available microarray applications using HSP90 as the target.