The altered activity of P53 signaling pathway by STK11 gene mutations and its cancer phenotype in Peutz-Jeghers syndrome

Yu-Liang Jiang,Zi-Ye Zhao,Bai-Rong Li,Fu Yang,Jing Li,Xiao-Wei Jin,Hao Wang,En-Da Yu,Shu-Han Sun,Shou-Bin Ning

The altered activity of P53 signaling pathway by STK11 gene mutations and its cancer phenotype in Peutz-Jeghers syndrome

2018

Yu-Liang Jiang
Zi-Ye Zhao
Bai-Rong Li
Fu Yang
Jing Li
Xiao-Wei Jin
Hao Wang
En-Da Yu
Shu-Han Sun
Shou-Bin Ning

Background Peutz-Jeghers syndrome (PJS) is caused by mutations in serine/threonine kinase 11 (STK11) gene. The increased cancer risk has been connected to P53 pathway.

Keywords:

Genetics
Peutz–Jeghers syndrome
Cancer research
STK11
Cancer
Cytogenetics
Phenotype
Human genetics
Gene
Biology
Kinase
gene mutation
Serine

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