BENZOLACTAM GROWTH HORMONE SECRETAGOGUES : REPLACEMENT OF THE C-3 AMIDE BOND IN L-692,429
1996
Abstract The synthesis and structure-activity relationships of various C-3 amide bond modifications in the novel nonpeptidyl growth hormone secretagogue L-692,429 are described. Several C-3 amide surrogates were prepared and the urea moiety was found to exhibit growth hormone releasing activity similar to that observed with L-692,429.
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