[Neonatal injections of pharmacological agents and their remote genotype-dependent effects in mice and rats].

Experimental data were reviewed which demonstrated that the neonatal injection effects of cer� tain biologically active drugs (ACTH4-10 fragment and its analogue Semax, piracetam, caffeine, levetirace� tam, busperone, etc.) could be detected in adult animals as changes in physiological and behavioral reactions and in several morphological traits as well. Audiogenic seizures proneness, anxietyfear and exploration behavior as well as pain sensitivity were analyzed. The remote effects discovered were either similar in direc� tion to those applied to an adult organism, or opposite to it. Pharmacological treatments of such type pre� sumably interfere the CNS development during early postnatal ontogeny and change the normal pattern of brain development. These modulatory influences could be due to changes in neurotransmitter system devel� opment and are presumably capable to induce CNS morphological deviations (numbers of neurons, adult neurogenesis).