Synthesis and Antimicrobial Evaluation of Novel 4-Methyl-7-((5-Aryl-4 H -1,2,4-Triazol-3-Yl)Methoxy)-2H-Benzopyran-2-Ones

A new series of 4-methyl-7-triazolylmethoxy-2H-benzopyran-2-ones were synthesized using 7-hydroxy-4-methyl-2H-benzopyran-2-one as the starting material. It was first converted into 7-yloxyacetohydrazide by functional group inter conversion strategies and then reacted with aromatic or heterocyclic aldehydes and ammonium acetate in acetic acid to give the titled compounds. All the synthesized compounds were evaluated for their in vitro antibacterial and antifungal activities against seven strains of bacteria and four strains of fungi. MIC results of most of the synthesized compounds (14-23, 26-27 and 29) have shown them to possess promising to comparable activities while compounds 15, 19, 21, 26, 27 and 29 were found to be better antifungal agents than the standard drugs in vitro and can serve as lead molecules to discover a new antimicrobial in future to combat the growing drug resistance and infections developed by various microorganisms.