Expression of IGF-1 in Gastric Cancer and Its Relationship with Cancer Invasion and Metastasis

[Purpose] To investigate the expression of IGF-1 and its relationship with invasion and metastasis in gastric cancer.[Methods] IGF-1 expression in sample tissues of 436 cases with gastric cancer and 92 cases of cancer adjacent gastric mucosa was detected immunohistochemically.[Results] IGF-1 expression in cancer adjacent gastric mucosa was significantly lower than that in gastric cancer tissues(0 vs 49.5%,χ2= 77.132,P0.001).IGF-1 expression was related to tumor size,differentiation,depth of invasion,stage,lymph node metastasis,distant metastasis,vascular invasion,Lauren classification of gastric cancer,except the histologic type and gender.IGF-1 positive expression rate in gastric cancer patients with tumor size≥5cm(64.4%) increased significantly than that in patients with tumor size 5cm(39.1%,χ2= 27.238,P0.001).IGF-1 positive expression rate in patients with diffusing type cancer(85.0%) increased significantly than that in intestinal-type cancer(15.7%,χ2=209.184,P0.001).IGF-1 positive expression rate in patients stage T3 and T4(62.7% and 92.3%) increased significantly than that in T1 and T2 stage patients(10.5% and 30.3%,χ2=86.830,P0.001).IGF-1 positive expression rate in patients with vascular invasion(71.5%) increased significantly than that in patients without vascular invasion(19.1%,χ2=116.710,P0.001).IGF-1 positive expression rate in patients with lymph node metastasis(70.0%)increased significantly than that in patients without lymph node metastasis(16.3%,χ2=118.740,P0.001).IGF-1 positive expression rate in patients with distant metastasis(95.1%) increased significantly than that in patients without distant metastasis(42.1%,χ2=58.841,P0.001).[Conclusion] IGF-1 relates to the carcinogenesis of gastric cancer,and involves in the process of invasion and metastasis of gastric cancer.IGF-1 expression could be used as an important reference indicator for biological behavior for gastric cancer.