New tumor necrosis factor-alpha biologic therapies for rheumatoid arthritis.

INTRODUCTION Rheumatoid arthritis is a chronic inflammatory cytokine-mediated disease, characterized by synovitis and joint erosions, with a high worldwide prevalence rate (~ 1%). Overall, rheumatoid arthritis is more common in women than in men, but this excess is greater in younger people; the incidences in women and men are similar in the elderly [1-3]. The large majority of patients with aggressive disease will become [...]