Meta-analysis of the association between Trp64Arg polymorphism in β3-adrenergic receptor gene and overweight/obesity in children

In this study, PubMed, Embase, China National Knowledge Infrastructure, databases VIP Chinese Periodical Database, and Wanfang Chinese Periodical Database were systematically searched for the case-control study related β3-adrenergic receptor(ADRB3) Trp64Arg gene polymorphism to overweight/obesity among children from 1962 to 2014. Twelve eligible studies with 2 222 overweight/obese children and 1 955 normal children were included according the uniform inclusion and exclusion criteria. Meta-analyses showed that Trp64Arg polymorphism was associated with significantly increased overweight/obesity risk in Arg carriers among children(OR=1.34, 95%CI 1.17-1.53). After stratification for ethnicity, highly significant coorelation of Trp64Arg polymorphism to overweight/obesity in Asian children(OR=1.44, 95%CI 1.23-1.68) but not significant in Europe(OR=1.05, 95%CI 0.79-1.40). It suggested that Trp64Arg polymorphism is associated with overweight/obesity susceptibility in children. Our results support an strong association between Trp64Arg polymorphism and overweight/obesity among the Asian children investigated. (Chin J Endocrinol Metab, 2016, 32: 121-124) Key words: β3-adrenergic receptor; Polymorphism; Children; Obesity; Meta-analysis