Pharmacokinetics (PK) of split-dose flavopiridol (F) administered with CPT-11 (CPT) and cisplatin (Cis)

2578 Background: F, a cyclin-dependent kinase inhibitor, induces tumor lysis in CLL when administered as a 30 mg/m2 loading dose over 0.5h followed by a 30 mg/m2 maintenance dose over 4h (hybrid F;...