Structural basis of cofactor-mediated stabilization and substrate recognition of the α-tubulin acetyltransferase αTAT1

Tubulin acetylation by the enzyme αTAT1 regulates microtublules that participate in various events including cell division and cellular transport. Here we show quantity control of αTAT1 by its cofactor (acetyl-CoA and CoA)-mediated stabilization and molecular mechanism for substrate recognition of αTAT1