ACUTE AND SUB-CHRONIC TOXICITY STUDY OF DREGEA VOLUBILIS FRUIT IN MICE

In present study, the safety profile of Dregea volubilis fruits was evaluated by acute and sub-chronic toxicity study of the petroleum ether extract of D. volubilis fruit (PEDV) in Swiss albino mice. The oral median lethal dose (LD50) of PEDV was found to be 900 mg/kg body weight. For sub-chronic toxicity study PEDV was administered at the single daily dose of 200 mg/kg for 28 consecutive days and at 29th day the hematological, histological, serum and liver biochemical parameters were evaluated by sacrificing the animals. No mortality was observed during the course of whole study. No detectable alterations were found in hematological biochemical and histological parameters in PEDV treated group when compared to vehicle control group after 28 days. The results of present study therefore indicate that D. volubilis fruit is safe in Swiss mice demonstrating no noticeable toxicity. Key words: Sub-chronic toxicity, Dregea volubilis , biochemical, LD 50 Moulisha Biswas et al. Acute and Sub-chronic Toxicity Study of Dregea volubilis Fruit in Mice. J Phytol 2/8 (2010) 06-10.