Determining the effects of socioeconomic and environmental determinants on chronic obstructive pulmonary disease (COPD) mortality using geographically and temporally weighted regression model across Xi'an during 2014-2016.

Numerous methods have been implemented to evaluate the relationship between environmental factors and respiratory mortality. However, the previous epidemiological studies seldom considered the spatial and temporal variation of the independent variables. The present study aims to detect the relations between respiratory mortality and related affecting factors across Xi'an during 2014-2016 based on a novel geographically and temporally weighted regression model (GTWR). Meanwhile, the ordinary least square (OLS) and the geographically weighted regression (GWR) models were developed for cross-comparison. Additionally, the spatial autocorrelation and Hot Spot analysis methods were conducted to detect the spatiotemporal dynamic of respiratory mortality. Some important outcomes were obtained. Socioeconomic and environmental determinants represented significant effects on respiratory diseases. The respiratory mortality exhibited an obvious spatial correlation feature, and the respiratory diseases tend to occur in winter and rural areas of the study area. The GTWR model outperformed OLS and GWR for determining the relations between respiratory mortality and socioeconomic as well as environmental determinants. The influence degree of anthropic factors on COPD mortality was higher than natural factors, and the effects of independent variables on COPD varied timely and locally. The results can supply a scientific basis for respiratory disease controlling and health facilities planning.