Synthesis and crystal structure of 3′-fluoro-3′-methyl-2′,3′-dideoxythymidine. inhibitory properties of 3′-fluoro-3′-methyl-2′,3′-dideoxythymidine-5′-triphosphate in the synthesis of DNA in cell-free media
1994
Abstract The synthesis, physicochemical properties and chain-termination properties of 3′-fluoro-3′-methyl-2′-3-dideoxythymidine is described. The synthesis was accomplished b the coupling of bis(TMS)thymine with 3-fluoro-3-methyl-2,3-dideoxy-D-erythro-pentose which is obtained from non-carbohydrate precursors.
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