ОЦІНКА АНТИБАКТЕРІАЛЬНИХ ТА ПРОТИГРИБКОВИХ ВЛАСТИВОСТЕЙ СУЧАСНИХ АНТИСЕПТИКІВ

Aim. Estimation of antimicrobial characteristics of decamethoxin, aethonium, decasan, miramistin, chlohexidine digluconate against bacteria and Candida albicans. Methods. There were studied such antiseptics as decamethoxin (DCM), aethonium (AET), decasan (DC), miramistin (MR), chlohexidine digluconate (CHG). The influence of DCM, AET on infusorium Colpoda steinii, cultures of cells of chorionic allantois membrane (CAM) of chick’s embryo was studied by means of standard methods. Antimicrobial activity of DCM, DC, MR, CHG, AET against clinical strains of S. aureus (n 65), Enterococcus spp. (n 23), E. coli (n 55), P. аureginosa (n 18), A. baumannii (n 46), Enterobacter spp. (n 10), K. pneumoniae (n 12), Proteus spp. (n 15) C. albicans (n 20) was determined by means of serial dilution method. Results. It was proved, that DCM after 3 hour of exposition had toxic action on Colpoda steinii culture and culture of CAM cells in lower dose (less than 25 mkg/ml), than AET (less than 125 mkg/kg). Antimicrobial activity of DC, MR, CHG, AET was found against S. aureus, Enterococcus spp. S. aureus. Minimal bactericidal concentrations (MBcC) of DC were above 4.31±0.48 mkg/ml, MBcC of AET – 17.94±6.63 mkg/ml. Enterococcus spp. were found to be sensitive to DC (MBcC 4.45±0.38 mkg/ml), CHG – (MBcC 21.37±1.91 mkg/ml). DC was active against E. coli (MBcC 9.43±0.49 mkg/ml). Clinical strains of C. albicans were more resistant to MR, CHG, AET comparatively to DC. Conclusion. Decamethoxin remedy (25 mkg/ml) and aethonium (125 mkg/ml) did not have any toxic action on Colpoda steinii, culture and culture of CAM cells for 3 hours of exposition. DC, MR, CHG and AET have strong antimicrobial activity against antibiotic-resistant strains of Gram-positive bacteria, C. albicans. DC, MR have better antimicrobial activity against antibiotic-resistant strains of bacteria in comparison of chlorhexidine, aethonium.