Organocatalytic Asymmetric Synthesis of Substituted 3-Hydroxy-2-oxindoles via Morita-Baylis-Hillman Reaction
2010
We report a highly enantioselective Morita−Baylis−Hillman (MBH) reaction of isatins and acrolein to provide enantiomerically enriched 3-substituted 3-hydroxyoxindoles, which could serve as valuable synthetic building blocks. This is also the first time that a ketone has been used as the electrophile and acrolein as the nucleophile in a highly enantioselective catalytic asymmetric MBH reaction. Hatakeyama’s catalyst, β-isocupreidine (1), turned out to be a powerful catalyst for this transformation.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
82
References
208
Citations
NaN
KQI