The Influence of Serotonin on Seizure Susceptibility in the Gerbil

5-hydroxytryptophan (5-HTP) (50 mg/kg, I.P.) increased central serotonin (5-HT) levels and delayed the onset of seizure during reflow in gerbils subjected to transient bilateral blockade with dimethyl tryptamine (DMT) (10 mg/kg I.P.) caused early onset of seizure. Results support an influence of 5-HT on seizure threshold in the central nervous system of the gerbil.