Protein misfolding in neurodegenerative diseases : mechanisms and therapeutic strategies

Protein Folding and Misfolding, Relevance to Disease and Function Massimi Stefani Alzheimer's Disease Charlotte E. Teunissen and Tischa M. van der Cammen Improving Cholinergic Transmission Cholinergic Transmission and Acetylcholine release Enhancers Pierre Francotte, Pascal de Tullio and Bernard Pirotte AChE and its Inhibition Jure Stojan AChE Inhibitors and their Clinical Assessment Pierre Francotte, Pascal de Tullio and Bernard Pirotte Reduction in Plaque Formation Christian Czech, Helmut Jacobsen and Celine Adessi Non-Steroidal Anti-inflammatory Drugs (NSAIDs) Bruno P. Imbimbo and Francesca Speroni Hydroxy-3-Methyl-Glutaryl-Coenzyme Reductase Inhibitors Dario Cattaneo Ass Polymerization Reduction Harry LeVine III and Corrine E. Augelli-Szafran Carbonic Anhydrase Activators as Potential Anti-Alzheimer's Disease Agents Claudiu T. Supuran and Andrea Scozzafava Detection and Reduction of Neurofibrillary Lesions Jeff Kuret Protein Misfolding in Alzheimer Disease: Pathogenic or Protective? Rudy J. Castellani, Hyoung-Gon Lee, Akihiko Nunomura, Xiongwei Zhu, Gorge Perry, and Mark A. Smith Enhancement of Brain Retinoic Acid Levels Ann B. Goodman, Peter McCaffery, Joana A. Palha, Claire Simons and Arthur B. Pardee Parkinson's Disease: What is it? What Causes it? And How Can it be Cured? Tom Foltynie, Andrew W. Michell and Roger A. Barker Restoring Dopamine Levels Nuno Palma, Maria Joao Bonifacio, Luis Almeida and Patricio Soares-da-Silva Huntington's Disease Claire-Anne Gutekunst and Fran Norflus Amyotrophic Lateral Sclerosis (Motor neuron Disease) Teresa Sanelli, Janice Robertson, Avi Chakabartty and Michael J Strong Transmissible Spongiform Encephalopathies (TSEs) Michael D. Geschwind and Giuseppe Legname Overview H. John Smith, Claire Simons and Robert D.E. Sewell