PP052-MON: Intestinal Fatty Acid Binding Protein as a Potential Marker of Small Bowel Damage After Large Intestine Resection

Rationale: There are no reports about the differences of energy metabolism in UC patients between active and remission stages. We analyzed the energy expenditure of hospitalized UC patients before and after induction therapy. Methods: Eleven hospitalized patients (8 males and 3 females; mean age 39.4 years old; mean BMI 19.3 kg/m2) with severe or moderate UC were enrolled in this study. We measured the resting energy expenditure (REE), respiratory quotients (RQ) of these patients before and after induction therapy by using indirect calorimetry. We examined the relationship between energy metabolism and activity index (Seo’s CAI and Lichtiger’s CAI), nutritional status and serum inflammatory cytokine levels. Prednisolone was administered in all patients. Cyclosporine or taclorimus therapy had just been started in 3 patients, and anti-TNF-a antibody therapy had been started in 2 patients. Results: The REE of severe or moderate UC patients was 26.5±3.4 kcal/kg/day in active stage, and significantly decreased to 23.4±2.3 kcal/kg/day after induction therapy (p < 0.01). RQ also were increased after induction therapy (p = 0.08). The REEs significantly correlated with activity index and with inflammatory cytokine IL-6. However, there was no significant correlation between REE and serum albumin levels or BMI. Conclusion: Severe or moderate UC patients showed a hyper-metabolic status, and energy expenditure dramatically decreased after induction therapy. It is likely that disease activity affect energy metabolism of UC patients via inflammatory cytokine IL-6. From our result, we recommend that nutritional management with 30 34 kcal/kg/day for hospitalized UC patients.