Sesquiterpene lactone extract from native american herbs demonstrated antineoplastic activity against Non Hodgkin Lymphoma cells

In the present work, the ability of Sesquiterpene lactone compound obtained from Magnolia extract and Parthenolide was studied for its ability to induce apoptosis of Follicular NHL cells in vitro. FNHL cells were obtained from stage IV patient, cultivated in presence of Magnolia’s extract, Parthenolide, both compounds or AIM-V medium. Samples were taken from these cultures for apoptosis and cytotoxicity analysis by flow cytometry (annexin V) and trypan blue exclusion assay. Both Magnolia extract and Parthenolide have showed apoptosis and cytotoxic properties on NHL cells. This evidence suggests that SQL compounds extracted from common herbs like Magnolia might be promising therapy strategies in treating NHL illness.