892 The myocardial performance index in hypertension patients with mild diastolic dysfunction and normal ejection fraction

The DopplerKlerived Myocardial Pedormance Index((MPI) which is defined as the sum of isovolumetric contraction time (ICT) and isovolumetric relaxation lime (IRT) divided by ejection time (ET) reflects systolic and diastolic function. Is easily obtainable and reproducible, has been suggested to be independent of heart rate, blood pressure or ventricular geometry and is used in the evaluation el lelt ventricular (LV) function in several pathologies. In patients with systemic hypertension (SH) and isolated diastolic dysfunction (DD) the diagnostic utility el this index remains unclear. Aim: This study was designed to determine the diagnostic utility el MPI in the assessment of SH patients with mild diastolic dysfunction and normal ejection lraction (EF). Methods: Were selected and compared regarding the MPI, 78 subjects with normal echocardiogram (22 male, 35-{-8 years) and 77 patients with SH (34 male, 66±11 years), and criteria lot DD defined as: E/A ratio 220 milliseconds (ms); ratio el mitral velocity to early diastolic velocity on the septal side of the mitral annulus (E/Em ratio) >8; peak septal Em wave velocity (Era) 0.33 as cutoll point (derived Item ROC curve analysis) SH patient with DD was identified with a accuracy el 65%, sensitivity el 57%, specificity of 73% and a false negative rate of 43°/0. Conclusions: Our results show that the MPI was of limited value in systemic hypertension patients with isolated mild diastolic dysfunction.