The first experience of using alteplase in the treatment of venous thromboembolic complications in women while taking oral contraceptives

Introduction . Pulmonary embolism (PE) is potentially life-threatening complication that could develop in hormonal contraceptive users. Therapeutic thrombolysis is safe, relatively modern and effective method of treatment. Aim of the study — to summarize our own experience of thrombolytic therapy of PE in women OC users. We presented three cases of PE developed in association with oral contraceptive use. Tree female patients aged 20 years, 34 years, 47 years at admittance to hospital were diagnosed PE. Result . All patients got thrombolytic therapy with alteplase 100 mg iv (10 mg bolus iv, then 90 mg continuous iv injection by infusomat). Good clinical outcomes were reached in all cases. Conclusion. Our experience shows that alteplase is highly effective agent in PE treatment in women with TE after hormonal contraception. Keywords: hormonal contraception; venous thrombosis; pulmonary embolism; thrombolysis.