Efforts toward the synthesis of (+)-Lyconadin A

Synthetic efforts toward the synthesis of (+)-lyconadin A are described. B-Alkyl Suzuki coupling is utilized for combining 2-iodo cyclohexenone with the piperidine subunit. The piperidine subunit is derived from 5-bromo-3-nicotinic acid, and iodo cyclohexenone from commercially available (R)-pulegone. An intramolecular Michael reaction is employed for the creation of the C6-C7 bond. Synthetic efforts toward the synthesis of (+)-lyconadin A are described. B-Alkyl Suzuki coupling is utilized to combine 2-iodo cyclohexenone with the piperidine subunit. The piperidine subunit is derived from 5-bromo-3-nicotinic acid, and iodo cyclohexenone from commercially available (R)-pulegone. An intramolecular Michael reaction is employed for creation of the C6-C7 bond.