IN VIVO REVERSAL OF THE ANTICOAGULANT EFFECT OF RIVAROXABAN WITH 4-FACTOR PROTHROMBIN COMPLEX CONCENTRATE
2014
Rivaroxaban lacks a specific reversal agent. Fifty units/kg of 4-factor prothrombin complex concentrate (PCC, Cofact®) completely reversed the anticoagulant effect of rivaroxaban in healthy subjects (Eerenberg, Circulation 2011;124:1573). We hypothesized that infusion with doses of 37.5 or 25 units
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