IN VIVO REVERSAL OF THE ANTICOAGULANT EFFECT OF RIVAROXABAN WITH 4-FACTOR PROTHROMBIN COMPLEX CONCENTRATE

Whitney Cheung,Stefano Barco,Michiel Coppens,Barbara A. Hutten,Joost C. M. Meijers,Saskia Middeldorp

IN VIVO REVERSAL OF THE ANTICOAGULANT EFFECT OF RIVAROXABAN WITH 4-FACTOR PROTHROMBIN COMPLEX CONCENTRATE

2014

Whitney Cheung
Stefano Barco
Michiel Coppens
Barbara A. Hutten
Joost C. M. Meijers
Saskia Middeldorp

Rivaroxaban lacks a specific reversal agent. Fifty units/kg of 4-factor prothrombin complex concentrate (PCC, Cofact®) completely reversed the anticoagulant effect of rivaroxaban in healthy subjects (Eerenberg, Circulation 2011;124:1573). We hypothesized that infusion with doses of 37.5 or 25 units

Keywords:

Rivaroxaban
In vivo
Prothrombin complex concentrate
Anticoagulant effect
Diabetes mellitus
Medicine
Cardiology
Pharmacology
Internal medicine
healthy subjects

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