Clinical Observation on Orally Taken Minocycline Combined with Externally Used Derma Light in Treatment of Severe Acne Vulgaris

Objective: To investigate the clinical therapeutic effects of orally taken minocycline combined with externally used Derma light on severe acne vulgaris,and to provide theoretic foundations for clinical treatment. Method: 80 patients meeting the criteria were selected and randomly divided into observation group and control group,40 patients in each group. The control group orally took minocycline,while the observation group orally took minocycline in combination with externally used Derma light,and the clinical therapeutic effects were compared 8 weeks after the therapies.Result: 8 weeks after the therapies,the total effective rate of the observation group was 97.50%,significantly higher than that of the control group( 80.00%),and the difference was statistically significant( P0.05). Before the treatment,the GAGS scores in the patients of the two groups were similar,and the difference was statistically insignificant( P0.05); after the treatments,the GAGS scores in the patients of both groups were decreased when compared with those before the treatments,and the differences were statistically significant( P0.05),but the GAGS scores in patients of the observation group were decreased more significantly( P0.05). During the treatment,2 patients of the observation group suffered from mild flushing,itching and desquamation in the facial skin after redblue light-struck,and the symptoms were relieved in 1 week after symptomatic treatments. No adverse reaction occurred in the control group. All the patients were followed up for 3 months,2 patients of the observation group relapsed( 5.00%),while 8 patients of the control group relapsed( 20.00%),and the difference was statistically significant( P0.05). Conclusion: Orally taken minocycline combined with externally used Derma light in treatment of severe acne vulgaris has positive clinical therapeutic effects,It is safe and reliable,has low recurrence rate,and consequently is worthy of clinical application.