K. pneumoniae and beta-lactamases. A rising issue

The increase in bacterial resistance is a rising phenomenon around the world, Klebsiella pneumoniae is one of the most important pathogens causing nosocomial infection being also associated to high resistance to beta-lactam antibiotics, mostly due to the presence of enzymes known as beta-lactameses. s-lactam antibiotics are the most prescribed antibiotics throughout the world, its use corresponding to approximately 50% of global use. The following review highlights the importance of the study and detection of B-lactamases in K. penaumoniae strains. The following paper describes the importance of K. pneumoniae as a nosocomial pathogen in the country and in the city and compares the situation to other areas of the world. A description of B-lactamases, their classification and target substrates is provided. In addition, the methods for detection of these enzymes by the clinical laboratory is also provided.