Hydrogenation of bis-α,β-unsaturated enones mediated by filamentous fungi

Abstract In this study was used two strains of marine-derived fungi ( Penicillium citrinum CBMA1186 and Trichoderma sp. CBMAI 932) and two strains of terrestrial fungi ( Aspergillus sp. FPZSP 146 and Aspergillus sp. FPZSP 152) to biotransformation bis-α,β-unsaturated ketones 1 – 2 to their corresponding 1,5-diphenylpentan-3-one ( 1a ), ( E )-1,5-diphenylpent-1-en-3-one ( 1b ), 1,5-diphenylpentan-3-ol ( 1c ), ( E )-1,5-diphenylpent-1-en-3-ol ( 1d ), 1,5-bis(4-methoxyphenyl)pentan-3-one ( 2a ), ( E )-1,5-bis(4-methoxyphenyl)pent-1-en-3-one ( 2b ) and 1,5-bis(4-methoxyphenyl)pentan-3-ol ( 2c ). The products were obtained in up to 84% conversion employing cultural broth and whole mycelia of mentioned fungi.