Synthesis, characterization, and in vivo evaluation of tumor targeting N-(2-hydroxypropyl)methacrylamide copolymer conjugates containing sulfamethazine groups

Recent studies have identified that sulfadiazine derivatives can be concentrated in the hepatocellular carcinoma tissue. Herein, we report the synthesis, characterization, and evaluation of a novel sulfamethazine N-(2-hydroxypropyl)methacrylamide copolymer conjugates for tumor targeting. N-(3-Aminopropyl)methacrylamide-diethylenetriaminepentaacetic acid monomer 1, methacryloyl-sulfamethazine monomer 2, poly(N-(2-hydroxypropyl)methacrylamide)-sulfamethazine-diethylenetriaminepentaacetic acid conjugate 4, and poly(N-(2-hydroxypropyl)methacrylamide)-sulfamethazine-diethylenetriaminepentaacetic acid-99mTc were successfully synthesized and characterized. Poly(N-(2-hydroxypropyl)methacrylamide)-diethylenetriaminepentaacetic acid conjugate 3, diethylenetriaminepentaacetic acid-99mTc, and poly(N-(2-hydroxypropyl)methacrylamide)-diethylenetriaminepentaacetic acid-99mTc were also synthesized and characterized for comparison (99mTc: metastable technetium-99). A 24-h necropsy data in the hepatocellular carcinoma tumo...