Bone status of Indian children and adolescents with type 1 diabetes mellitus

Abstract Objective Low bone mineral density has been reported in children and adolescents with type 1 diabetes (T1DM). The aims of this cross-sectional study were to study growth, serum IGF1 concentrations and bone health parameters assessed by Dual Energy X-ray Absorptiometry (DXA). Methods Height was measured and converted to Z scores (HAZ). Serum IGF1 concentrations were measured (ELISA) in a subset. Bone mineral content for total body (less head) (TBBMC) and lumbar spine was measured (n = 170, 77 boys, 6–16 years old) and converted to Z scores using local normative data. Result Mean age was 11.1 ± 3.8 years, disease duration was 2.2 ± 2.5 years and HbA1C was 10.1 ± 1.8%. Diabetic children were shorter than reference population (HAZ − 0.6 ± 1.1); Z scores for height and total body bone area (TBBA) for height were Conclusion Longer duration of diabetes was associated with shorter and slender but appropriately mineralized bones. Small and slender bones in diabetic children may increase risk of fragility fractures in the future. This article is part of a Special Issue entitled “Bone and diabetes” .