Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas
2018
- Franz X. Schaub
- Varsha Dhankani
- Ashton C. Berger
- Mihir Trivedi
- Anne B. Richardson
- Reid Shaw
- Wei Zhao
- Xiaoyang Zhang
- Andrea Ventura
- Yuexin Liu
- Donald E. Ayer
- Peter J. Hurlin
- Andrew D. Cherniack
- Robert N. Eisenman
- Brady Bernard
- Carla Grandori
- Samantha J. Caesar-Johnson
- John A. Demchok
- Ina Felau
- Melpomeni Kasapi
- Martin L. Ferguson
- Carolyn M. Hutter
- Heidi J. Sofia
- Roy Tarnuzzer
- Zhining Wang
- Liming Yang
- Jean C. Zenklusen
- Jiashan (Julia) Zhang
- Sudha Chudamani
- Jia Liu
- Laxmi Lolla
- Rashi Naresh
- Todd Pihl
- Qiang Sun
- Yunhu Wan
- Ye Wu
- Juok Cho
- Timothy DeFreitas
- Scott Frazer
- Nils Gehlenborg
- Gad Getz
- David I. Heiman
- Jaegil Kim
- Michael S. Lawrence
- Pei Lin
- Sam Meier
- Michael S. Noble
- Gordon Saksena
- Doug Voet
- Hailei Zhang
- Nyasha Chambwe
- Theo Knijnenburg
- Roger Kramer
- Kalle Leinonen
- Michael B. Miller
- Sheila Reynolds
- Ilya Shmulevich
- Vesteinn Thorsson
- Wei Zhang
- Rehan Akbani
- Bradley McIntosh Broom
- Apurva M. Hegde
- Zhenlin Ju
- Rupa S. Kanchi
- Anil Korkut
- Jun Li
- Han Liang
- Shiyun Ling
- Wenbin Liu
- Yiling Lu
- Gordon B. Mills
- Kwok-Shing Ng
- Arvind Rao
- Michael T. Ryan
- Jing Wang
- John N. Weinstein
- Jiexin Zhang
- Adam Abeshouse
- Joshua Armenia
- Debyani Chakravarty
- Walid K. Chatila
- Ino de Bruijn
- Jianjiong Gao
- Benjamin E. Gross
- Zachary J. Heins
- Ritika Kundra
- Konnor La
- Marc Ladanyi
- Augustin Luna
- Moriah G. Nissan
- Angelica Ochoa
- Sarah M. Phillips
- Ed Reznik
- Francisco Sanchez-Vega
- Chris Sander
- Nikolaus Schultz
- Robert L. Sheridan
- S. Onur Sumer
- Yichao Sun
- Barry S. Taylor
- Jioajiao Wang
- Hongxin Zhang
- Pavana Anur
- Myron Peto
- Paul T. Spellman
- Christopher C. Benz
- Joshua M. Stuart
- Chris K.C. Wong
- Christina Yau
- D. Neil Hayes
- Joel S. Parker
- Matthew D. Wilkerson
- Adrian Ally
- Miruna Balasundaram
- Reanne Bowlby
- Denise Brooks
- Rebecca Carlsen
- Eric Chuah
- Noreen Dhalla
- Robert A. Holt
- Steven J.M. Jones
- Katayoon Kasaian
- Darlene Lee
- Yussanne Ma
- Marco A. Marra
- Michael Mayo
- Richard A. Moore
- Andrew J. Mungall
- Karen Mungall
- A. Gordon Robertson
- Sara Sadeghi
- Jacqueline E. Schein
- Payal Sipahimalani
- Angela Tam
- Nina Thiessen
- Kane Tse
- Tina Wong
- Rameen Beroukhim
- Carrie Cibulskis
- Stacey Gabriel
- Galen F. Gao
- Gavin Ha
- Matthew Meyerson
- Steven E. Schumacher
- Juliann Shih
- Melanie H. Kucherlapati
- Raju Kucherlapati
- Stephen B. Baylin
- Leslie Cope
- Ludmila Danilova
- Moiz S. Bootwalla
- Phillip H. Lai
- Dennis T. Maglinte
- David Van Den Berg
- Daniel J. Weisenberger
- J. Todd Auman
- Saianand Balu
- Tom Bodenheimer
- Cheng Fan
- Katherine A. Hoadley
- Alan P. Hoyle
- Stuart R. Jefferys
- Corbin D. Jones
- Shaowu Meng
- Piotr A. Mieczkowski
- Lisle E. Mose
- Amy H. Perou
- Charles M. Perou
- Jeffrey Roach
- Yan Shi
- Janae V. Simons
- Tara Skelly
- Matthew G. Soloway
- Donghui Tan
- Umadevi Veluvolu
- Huihui Fan
- Toshinori Hinoue
- Peter W. Laird
- Hui Shen
- Wanding Zhou
- Michelle Bellair
- Kyle Chang
- Kyle R. Covington
- Chad J. Creighton
- Huyen Dinh
- HarshaVardhan Doddapaneni
- Lawrence A. Donehower
- Jennifer Drummond
- Richard A. Gibbs
- Robert Glenn
- Walker Hale
- Yi Han
- Jianhong Hu
- Viktoriya Korchina
- Sandra Lee
- Lora Lewis
- Wei Li
- Xiuping Liu
- Margaret Morgan
- Donna Morton
- Donna M. Muzny
- Jireh Santibanez
- Margi Sheth
- Eve Shinbrot
- Linghua Wang
- Min Wang
- David A. Wheeler
- Liu Xi
- Fengmei Zhao
- Julian Hess
- Elizabeth L. Appelbaum
- Michael Bailey
- Matthew G. Cordes
- Li Ding
- Catrina C. Fronick
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- Robert S. Fulton
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- Elaine R. Mardis
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- Christopher A. Miller
- Heather K. Schmidt
- Richard K. Wilson
- Daniel Crain
- Erin Curley
- Johanna Gardner
- Kevin Lau
- David Mallery
- Scott Morris
- Joseph Paulauskis
- Robert Penny
- Candace Shelton
- Troy Shelton
- Mark E. Sherman
- Eric M. Thompson
- Peggy Yena
- Jay Bowen
- Julie M. Gastier-Foster
- Mark Gerken
- Kristen M. Leraas
- Tara M. Lichtenberg
- Nilsa C. Ramirez
- Lisa Wise
- Erik Zmuda
- Niall M. Corcoran
- Tony Costello
- Christopher Hovens
- André Carlos Ponce de Leon Ferreira de Carvalho
- Ana C. de Carvalho
- José Humberto Tavares Guerreiro Fregnani
- Adhemar Longatto-Filho
- Rui Manuel Reis
- Cristovam Scapulatempo-Neto
- Henrique Silveira
- Daniel O. Vidal
- Andrew Burnette
- Jennifer Eschbacher
- Beth Hermes
- Ardene Noss
- Rosy Singh
- Matthew L. Anderson
- Patricia D. Castro
- Michael Ittmann
- David Huntsman
- Bernard Kohl
- Xuan Le
- Richard Thorp
- Chris Andry
- Elizabeth R. Duffy
- Vladimir Lyadov
- Oxana Paklina
- Galiya Setdikova
- Alexey Shabunin
- Mikhail Tavobilov
- Christopher McPherson
- Ronald E. Warnick
- Ross S. Berkowitz
- Daniel W. Cramer
- Colleen Feltmate
- Neil S. Horowitz
- Adam S. Kibel
- Michael G. Muto
- Chandrajit P. Raut
- Andrei Malykh
- Jill S. Barnholtz Sloan
- Wendi Barrett
- Karen Devine
- Jordonna Fulop
- Quinn T. Ostrom
- Kristen Shimmel
- Yingli Wolinsky
- Andrew E. Sloan
- Agostino De Rose
- Felice Giuliante
- Marc T. Goodman
- Beth Y. Karlan
- Curt H. Hagedorn
- John Eckman
- Jodi Harr
- Jerome Myers
- Kelinda Tucker
- Leigh Anne Zach
- Brenda Deyarmin
- Hai Hu
- Leonid Kvecher
- Caroline Larson
- Richard J. Mural
- Stella Somiari
- Ales Vicha
- Tomas Zelinka
- Joseph Bennett
- Mary Iacocca
- Brenda Rabeno
- Patricia Swanson
- Mathieu Latour
- Louis Lacombe
- Bernard Têtu
- Alain Bergeron
- Mary McGraw
- Susan M. Staugaitis
- John Chabot
- Hanina Hibshoosh
- Antonia R. Sepulveda
- Tao Su
- Tim Wang
- Olga Potapova
- Olga Voronina
- L. Desjardins
- Odette Mariani
- Sergio Roman-Roman
- Xavier Sastre
- Marc-Henri Stern
- Feixiong Cheng
- Sabina Signoretti
- Andrew Berchuck
- Darell D. Bigner
- Eric Lipp
- Jeffrey R. Marks
- Shannon McCall
- Roger E. McLendon
- Angeles Alvarez Secord
- Alexis Sharp
- Madhusmita Behera
- Daniel J. Brat
- Amy Chen
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- Seth Force
- Fadlo R. Khuri
- Kelly R. Magliocca
- Shishir K. Maithel
- Jeffrey J. Olson
- Taofeek K. Owonikoko
- Alan Pickens
- Suresh S. Ramalingam
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- Gabriel Sica
- Erwin G. Van Meir
- Hongzheng Zhang
- Wil Eijckenboom
- Ad Gillis
- Esther Korpershoek
- Leendert Looijenga
- Wolter Oosterhuis
- Hans Stoop
- Kim E. van Kessel
- Ellen C. Zwarthoff
- Chiara Calatozzolo
- Lucia Cuppini
- Stefania Cuzzubbo
- Francesco DiMeco
- Gaetano Finocchiaro
- Luca Mattei
- Alessandro Perin
- Bianca Pollo
- Chu Chen
- John Houck
- Pawadee Lohavanichbutr
- Arndt Hartmann
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- Witold Kycler
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- Ki Chung
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- Steven N. Kalkanis
- Tom Mikkelsen
- Houtan Noushmehr
- Lisa Scarpace
- Nicolas Girard
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- Eva Giné
- Armando López Guillermo
- Nguyen Van Bang
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- Bui Duc Phu
- Yufang Tang
- Howard Colman
- Kimberley Evason
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- Teniola Akeredolu
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- Christel Herold-Mende
- Christin Jungk
- Andreas Unterberg
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- Mohammed M. Milhem
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- Sally N. Adebamowo
- Alex Boussioutas
- David G. Beer
- Thomas P. Giordano
- Anne-Marie Mes-Masson
- Fred Saad
- Therese Bocklage
- Lisa M. Landrum
- Robert S. Mannel
- Kathleen N. Moore
- Katherine Moxley
- Russel Postier
- Joan L. Walker
- Rosemary Zuna
- Michael Feldman
- Federico Valdivieso
- Rajiv Dhir
- James D. Luketich
- Edna M. Mora Pinero
- Mario Quintero-Aguilo
- Carlos Gilberto Carlotti
- José Sebastião dos Santos
- Rafael Kemp
- Ajith Sankarankuty
- Daniela Tirapelli
- James Catto
- Kathy Agnew
- Elizabeth M. Swisher
- Jenette Creaney
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- Jeffey Moyer
- Lisa Peterson
- Mark E. Prince
- Laura S. Rozek
- Gregory T. Wolf
- Rayleen Bowman
- Kwun M. Fong
- Ian A. Yang
- Robert Korst
- W. Kimryn Rathmell
- J. Leigh Fantacone-Campbell
- Jeffrey A. Hooke
- Albert J. Kovatich
- Craig D. Shriver
- John F. DiPersio
- Bettina F. Drake
- Ramaswamy Govindan
- Sharon Heath
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- Brian A. Van Tine
- Peter Westervelt
- Mark A. Rubin
- Jung-Il Lee
- Natália D. Aredes
- Armaz Mariamidze
Summary Although the MYC oncogene has been implicated in cancer, a systematic assessment of alterations of MYC, related transcription factors, and co-regulatory proteins, forming the proximal MYC network (PMN), across human cancers is lacking. Using computational approaches, we define genomic and proteomic features associated with MYC and the PMN across the 33 cancers of The Cancer Genome Atlas. Pan-cancer, 28% of all samples had at least one of the MYC paralogs amplified. In contrast, the MYC antagonists MGA and MNT were the most frequently mutated or deleted members, proposing a role as tumor suppressors. MYC alterations were mutually exclusive with PIK3CA , PTEN , APC , or BRAF alterations, suggesting that MYC is a distinct oncogenic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such as immune response and growth factor signaling; chromatin, translation, and DNA replication/repair were conserved pan-cancer. This analysis reveals insights into MYC biology and is a reference for biomarkers and therapeutics for cancers with alterations of MYC or the PMN.
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