Aminoglycoside Monitoring in Regional and Rural Hospitals: Room for Improvement?

However, growing concern regarding aminoglycoside toxicity, has led some clinicians to argue that aminoglycosides should be used rarely and replaced by other less toxic but generally more broad-spectrum antibiotics (e.g. carbapenems, broad-spectrum cephalosporins).1 Toxicity includes nephrotoxicity (generally reversible and more predictable, especially with prolonged exposure), and ototoxicity, including vestibular and auditory toxicity (less predictable and may be irreversible).