Cost-effectiveness of vaccines for the prevention of seasonal influenza in different age groups: a systematic review
2018
BACKGROUND: Given the economic burden of seasonal influenza for the healthcare system, we performed a systematic review aiming to update available evidence on the cost-effectiveness of vaccination of seasonal influenza in different age groups, including children. METHODS: A systematic review of the literature on economic evaluations of seasonal influenza vaccination programs in children and adults was carried out. The following databases were searched (January 2013 - April 2018): Medline and PREMEDLINE, EMBASE, EconLit and databases of the Centre for Reviews and Dissemination (DARE, HTA, NHS EED). RESULTADOS: Se incluyeron 11 evaluaciones economicas. La calidad metodologica de los estudios incluidos fue buena. La evidencia cientifica muestra que los programas de vacunacion contra la gripe estacional en ninos en edad escolar pueden ser una estrategia coste-efectiva desde la perspectiva sanitaria en paises europeos. La evidencia cientifica disponible hasta el momento no nos permite concluir que los programas de vacunacion antigripal en adultos sanos de menos de 65 anos de edad sean una alternativa costeefectiva en nuestro contexto, debido a la elevada incertidumbre existente y a la escasez de estudios realizados en el contexto espanol. CONCLUSIONS: Vaccination programs for the prevention of seasonal influenza in school-age children (3-16 years) can be a cost-effective strategy.
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